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Dosage and Administration Administration. Adapalene is applied topically to the skin as a 0.1% cream or 0.1% gel. Prior to application of the cream or gel, the affected areas should be cleansed and dried.

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Adapalene, sold as Differin® gel, is a topical retinoid similar to Vitamin A. Learn how topical retinoids work, and their side effects at Acne.com

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